Annona muricata (KAJIAN PEMANFAATAN DAN BIOAKTIVITASNYA DALAM KESEHATAN)
Keywords:
Annona muricata, anticancer, annonacin
Abstract
Annona muricata (AM) with the local name soursop is a multifunctional plant that is easily found in the yard which is used as a source of fruit, medicine and shade. In Indonesia in the 2000s, AM leaf was widely used as a cancer drug because it was considered safer and cheaper than synthetic drugs. Various facts show that the use of plants as traditional medicine sometimes causes side effects. This study aims to reveal the relationship between the use of AM as a traditional medicine and its bioactivity. The writing of this article is based on the study of literature in various books, research results and journals published online and offline by using the keywords Annona muricata and Annona muricata bioactivity. In ethnobotany AM is used as a treatment for intestinal worms, cancer, anti-hypertension, diabetes mellitus, headaches, fever, toothache, cough, and asthma. Various research results show that AM bioactivity as anti-Leismania, anti-helmet, anti-cancer, anti-oxidant, antidiabetic mellitus, and anti-malaria. Annonacin, acetogenin, and polyphenols are AM bioactive compounds that are known to have chemopreventive effects on cancer.
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References
Abdullah, M., Syam, A.F., Meilany, S., Laksono, B., Prabu, O.G., Bekti, H.S., Indrawati, L., & Makmun, D. (2017). The value of Caspase-3 after the application of Annona muricata leaf extract in COLO-205 colorectal cancer cell line. Gastroenterology Research and Practice. Article ID 4357165, 5 pages.
Asare, G.A., Afriyie, D., Ngala, R.A., Abutiate, H., Doku, D., Mahmood, S.A. & Rahman, H. (2015). Antiproliferative activity of aqueous leaf extract of annona muricata l. on the prostate, BPH-1 cells, and some target genes. Integrative Cancer Therapies 14(1): 65-74.
Adefegha, S.A., Oyeleye, S.I. & Oboh, G. (2015). Distribution of phenolic contents, antidiabetic potentials, antihypertensive properties, and antioxidative effects of soursop (Annona muricata L.) fruit parts in vitro. Biochemistry Research International. Article ID 347673, 8 pages.
Coria-Tellez, A.V., Montalvo-Gonzalez, E., Yahia, E.M. & Obledo-Vazquez, E.N. (2018). Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry 11: 662-691.
Elagbar, Z.A., Naik, R.R., Shakya, A.K. & Bardaweel, S.K. (2016). Fatty acids analysis, antioxidant and biological activity of fixed oil of Annona muricata L. seeds. Journal of Chemistry. Article ID 6948098, 6 pages.
Fidianingsih, I. & Handayani, E.S. (2014). Annona muricata aqueous extract suppresses T47D breast cancer cell proliferation. Univ Med 33: 19-26.
Ferreira, L.E., Castro, P.M.N., Chagas, A.C.S., França, S.C. & Beleboni, R.O. (2013). In vitro anthelmintic activity of aqueous leaf extract of Annona muricata L. (Annonaceae) against Haemonchus contortus from sheep. Experimental Parasitology 134: 327-332.
Foong, C.P. & Hamid, R.A. (2012). Evaluation of anti-infl ammatory activities of ethanolic extract of Annona muricata leaves. Brazilian Journal of Pharmacognosy 22(6): 1301-1307.
Gavamukuya, Y., Abou-Elella, F., Wamunyokoli, F. & Ael-Shemy, H. (2014). Phytochemical screening anti-oxidan activity an in vitro anticancer potential ot ethanolic and water level extracts of Annona muricata (graviola). Asian Pac J Trop Med 7(Supp1): s335-s363.
Indrawati, L., Ascobat, P., Bela, B., Abdullah, M. & Surono, I.S. (2017). The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial. Asia Pac J Clin Nutr. 26(4): 606-612.
Javed, F., Al-Hezaimi, K. & Warnakulasuriya, S. (2019). Areca-nut chewing habit is a significant risk factor for metabolic syndrome: a systematic review. The Journal of Nutrition, Health & Aging 1-4.
Kim, G.T., Tran, N.K.S., Choi, E.H., Song, Y.J., Song, J.H., Shim, S.M. & Park, T.S. (2016). Immunomodulatory efficacy of standardized Annona muricata (Graviola) leaf extract via activation of mitogen-activated protein kinase pathways in RAW 264.7 macrophages. Evidence-Based Complementary and Alternative Medicine. Article ID 2905127, 10 pages.
Liu, N., Yang, H.L., Wang, P., Lu, Y.C., Yang, Y.J., Wang, L. & Lee, S.C. (2016). Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway. Journal of Ethnopharmacology 89: 210-217.
Lai, R.S., Chiang, A.A., Wu, M.T., Wang, J.S., Lai, N.S., Lu, J.Y. & Ger, L.P. (1996). Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan. Lancet 348: 83-85.
Lopez-Vilchez, M.A., Seidel, V., I-Farre, M., Garcıa-Algar, O., Pichini, S. & Mur, A. (2006). Areca-nut abuse and neonatal withdrawal syndrome. Pediatrics 117 (1): 129-131.
Minari, J.B. & Okeke, U. (2014). Chemopreventive effect of Annona muricata on DMBA-induced cell proliferation in the breast tissues of female albino mice. The Egyptian Journal of Medical Human Genetics 15: 327-334.
Moghadamtousi, S.Z., Kadir, H.A., Paydar, M., Rouhollahi, E. & Karimian, H. (2014). Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB. BMC Complementary and Alternative Medicine 14(299): 1-13.
Pieme, C.A., Kumar, S.G., Dongmo, M.S., Moukette, B.M., Boyoum, F.F., Ngogang, J.Y. & Saxena, A.K. (2014). Antiproliferative activity and induction of apoptosis by Annona muricata (Annonaceae) extract on human cancer cells. BMC Complementary and Alternative Medicine 14(516): 1-10.
Munim, A. & Hanani, E. (2011). Fisioterapi Dasar. Dian Rakyat. Jakarta. viii + 356 hlm.
Prabhu, R.V., Prabhu, V., Chatra, L., Shenai, P., Suvarna, N. & Dandekeri, S. (2014). Areca nut and its role in oral submucous fibrosis. J Clin Exp Dent. 6(5): 569-575.
Silalahi, M. & Nisyawati. (2018). The ethnobotanical study of edible and medicinal plants in the home garden of Batak Karo sub-ethnic in North Sumatra, Indonesia, Jurnal Biodiversitas 19( 1): 621-631
Silalahi, M., Purba, E.C. & Mustaqim, W.A. (2019). Tumbuhan Obat Sumatera Utara Jilid II: Dikotiledonae. UKI Press, Jakarta 282 halaman.
Somsak, V., Polwiang, N. & Chachiyo, S. (2016). In vivo antimalarial activity of Annona muricata leaf extract in mice infected with Plasmodium berghei. Journal of Pathogens. Article ID 3264070, 5 pages.
Wahyono. (2008). Eksistensi dan perkembangan obat tradisional (jamu) dalam era obat modern. Pidato pengukuhan jabatan guru besar pada Fakultas Farmasi Universitas Gajah Mada. 28 april 2008 di Yogyakarta. p: 1-27
Vila-Nova, N.S., de Morais, S.M., Falcão, M.J.C., Alcantara, T.T.N., Ferreira, P.A.T., Cavalcanti, E.S.B., Vieira, I.G.P., Campello, C.C. & Wilson, M. (2013). Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone. Experimental Parasitology 133: 334-338.
Yang, C., Gundala, S.R., Mukkavilli, R., Vangala, S., Reid, M.D. & Aneja, R. (2015). Synergistic interactions among flavonoids and acetogenins in graviola (Annona muricata) leaves confer protection against prostate cancer. Carcinogenesis 36(6): 656–665
Yang, H.A., Liu, N. & Lee, S. (2016). Ethanol extract of Annona muricata. L induces liver cancer cell apoptosis through ROS pathway. Biomedical & Pharmacology Journal 9(3): 919-925.
Asare, G.A., Afriyie, D., Ngala, R.A., Abutiate, H., Doku, D., Mahmood, S.A. & Rahman, H. (2015). Antiproliferative activity of aqueous leaf extract of annona muricata l. on the prostate, BPH-1 cells, and some target genes. Integrative Cancer Therapies 14(1): 65-74.
Adefegha, S.A., Oyeleye, S.I. & Oboh, G. (2015). Distribution of phenolic contents, antidiabetic potentials, antihypertensive properties, and antioxidative effects of soursop (Annona muricata L.) fruit parts in vitro. Biochemistry Research International. Article ID 347673, 8 pages.
Coria-Tellez, A.V., Montalvo-Gonzalez, E., Yahia, E.M. & Obledo-Vazquez, E.N. (2018). Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry 11: 662-691.
Elagbar, Z.A., Naik, R.R., Shakya, A.K. & Bardaweel, S.K. (2016). Fatty acids analysis, antioxidant and biological activity of fixed oil of Annona muricata L. seeds. Journal of Chemistry. Article ID 6948098, 6 pages.
Fidianingsih, I. & Handayani, E.S. (2014). Annona muricata aqueous extract suppresses T47D breast cancer cell proliferation. Univ Med 33: 19-26.
Ferreira, L.E., Castro, P.M.N., Chagas, A.C.S., França, S.C. & Beleboni, R.O. (2013). In vitro anthelmintic activity of aqueous leaf extract of Annona muricata L. (Annonaceae) against Haemonchus contortus from sheep. Experimental Parasitology 134: 327-332.
Foong, C.P. & Hamid, R.A. (2012). Evaluation of anti-infl ammatory activities of ethanolic extract of Annona muricata leaves. Brazilian Journal of Pharmacognosy 22(6): 1301-1307.
Gavamukuya, Y., Abou-Elella, F., Wamunyokoli, F. & Ael-Shemy, H. (2014). Phytochemical screening anti-oxidan activity an in vitro anticancer potential ot ethanolic and water level extracts of Annona muricata (graviola). Asian Pac J Trop Med 7(Supp1): s335-s363.
Indrawati, L., Ascobat, P., Bela, B., Abdullah, M. & Surono, I.S. (2017). The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial. Asia Pac J Clin Nutr. 26(4): 606-612.
Javed, F., Al-Hezaimi, K. & Warnakulasuriya, S. (2019). Areca-nut chewing habit is a significant risk factor for metabolic syndrome: a systematic review. The Journal of Nutrition, Health & Aging 1-4.
Kim, G.T., Tran, N.K.S., Choi, E.H., Song, Y.J., Song, J.H., Shim, S.M. & Park, T.S. (2016). Immunomodulatory efficacy of standardized Annona muricata (Graviola) leaf extract via activation of mitogen-activated protein kinase pathways in RAW 264.7 macrophages. Evidence-Based Complementary and Alternative Medicine. Article ID 2905127, 10 pages.
Liu, N., Yang, H.L., Wang, P., Lu, Y.C., Yang, Y.J., Wang, L. & Lee, S.C. (2016). Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway. Journal of Ethnopharmacology 89: 210-217.
Lai, R.S., Chiang, A.A., Wu, M.T., Wang, J.S., Lai, N.S., Lu, J.Y. & Ger, L.P. (1996). Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan. Lancet 348: 83-85.
Lopez-Vilchez, M.A., Seidel, V., I-Farre, M., Garcıa-Algar, O., Pichini, S. & Mur, A. (2006). Areca-nut abuse and neonatal withdrawal syndrome. Pediatrics 117 (1): 129-131.
Minari, J.B. & Okeke, U. (2014). Chemopreventive effect of Annona muricata on DMBA-induced cell proliferation in the breast tissues of female albino mice. The Egyptian Journal of Medical Human Genetics 15: 327-334.
Moghadamtousi, S.Z., Kadir, H.A., Paydar, M., Rouhollahi, E. & Karimian, H. (2014). Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB. BMC Complementary and Alternative Medicine 14(299): 1-13.
Pieme, C.A., Kumar, S.G., Dongmo, M.S., Moukette, B.M., Boyoum, F.F., Ngogang, J.Y. & Saxena, A.K. (2014). Antiproliferative activity and induction of apoptosis by Annona muricata (Annonaceae) extract on human cancer cells. BMC Complementary and Alternative Medicine 14(516): 1-10.
Munim, A. & Hanani, E. (2011). Fisioterapi Dasar. Dian Rakyat. Jakarta. viii + 356 hlm.
Prabhu, R.V., Prabhu, V., Chatra, L., Shenai, P., Suvarna, N. & Dandekeri, S. (2014). Areca nut and its role in oral submucous fibrosis. J Clin Exp Dent. 6(5): 569-575.
Silalahi, M. & Nisyawati. (2018). The ethnobotanical study of edible and medicinal plants in the home garden of Batak Karo sub-ethnic in North Sumatra, Indonesia, Jurnal Biodiversitas 19( 1): 621-631
Silalahi, M., Purba, E.C. & Mustaqim, W.A. (2019). Tumbuhan Obat Sumatera Utara Jilid II: Dikotiledonae. UKI Press, Jakarta 282 halaman.
Somsak, V., Polwiang, N. & Chachiyo, S. (2016). In vivo antimalarial activity of Annona muricata leaf extract in mice infected with Plasmodium berghei. Journal of Pathogens. Article ID 3264070, 5 pages.
Wahyono. (2008). Eksistensi dan perkembangan obat tradisional (jamu) dalam era obat modern. Pidato pengukuhan jabatan guru besar pada Fakultas Farmasi Universitas Gajah Mada. 28 april 2008 di Yogyakarta. p: 1-27
Vila-Nova, N.S., de Morais, S.M., Falcão, M.J.C., Alcantara, T.T.N., Ferreira, P.A.T., Cavalcanti, E.S.B., Vieira, I.G.P., Campello, C.C. & Wilson, M. (2013). Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone. Experimental Parasitology 133: 334-338.
Yang, C., Gundala, S.R., Mukkavilli, R., Vangala, S., Reid, M.D. & Aneja, R. (2015). Synergistic interactions among flavonoids and acetogenins in graviola (Annona muricata) leaves confer protection against prostate cancer. Carcinogenesis 36(6): 656–665
Yang, H.A., Liu, N. & Lee, S. (2016). Ethanol extract of Annona muricata. L induces liver cancer cell apoptosis through ROS pathway. Biomedical & Pharmacology Journal 9(3): 919-925.
Published
2020-06-04
How to Cite
Silalahi, M. (2020). Annona muricata (KAJIAN PEMANFAATAN DAN BIOAKTIVITASNYA DALAM KESEHATAN). Husada Mahakam: Jurnal Kesehatan, 10(1), 52 - 62. https://doi.org/10.35963/hmjk.v10i1.203
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Copyright (c) 2020 Marina Silalahi
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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This work is licensed under a
Creative Commons Attribution-ShareAlike 4.0 International License
